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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:25

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Related Experiment Video

Updated: Apr 19, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
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Neural substrates underlying stimulation-enhanced motor skill learning after stroke.

Stéphanie Lefebvre1, Laurence Dricot2, Patrice Laloux1

  • 11 Université catholique de Louvain (UcL), CHU Dinant Godinne UcL Namur, Neurology Department, Avenue Dr G. Therasse, Yvoir 5530, Belgium 2 UcL, Institute of NeuroScience (IoNS), Brussels 1200, Belgium.

Brain : a Journal of Neurology
|December 10, 2014
PubMed
Summary

Dual transcranial direct current stimulation (tDCS) improves motor skill learning and retention in stroke patients. This neurorehabilitation technique enhances motor function recovery by optimizing brain activation patterns for lasting behavioral improvements.

Keywords:
fMRImotor skill learningneurorehabilitationstroketDCS

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Motor Control

Background:

  • Motor skill learning is crucial for post-stroke motor function recovery.
  • Transcranial direct current stimulation (tDCS) shows potential in enhancing neurorehabilitation and motor learning in stroke survivors.
  • Neural mechanisms of tDCS-enhanced motor skill learning retention in the paretic upper limb require further investigation.

Purpose of the Study:

  • To explore the neural mechanisms underlying the retention of tDCS-enhanced motor skill learning in chronic hemiparetic stroke patients.
  • To investigate the effects of dual tDCS on motor skill acquisition, retention, and transfer.
  • To examine brain activation patterns associated with tDCS-driven motor learning and recovery.

Main Methods:

  • A double-blind, cross-over, randomized, sham-controlled study involving 19 chronic hemiparetic stroke patients.
  • Dual tDCS or sham stimulation applied bilaterally over the primary motor cortex during a motor skill learning task (circuit game).
  • Functional magnetic resonance imaging (fMRI) used to assess brain activation 1 week after the intervention session.

Main Results:

  • Dual tDCS significantly enhanced online motor skill learning, 1-week retention, and transfer to an untrained task compared to sham.
  • tDCS intervention showed a trend towards normalizing brain activation patterns during learned skill performance.
  • Lasting behavioral enhancement was linked to more efficient motor skill network recruitment, particularly in the dorsal premotor cortex of the damaged hemisphere.

Conclusions:

  • Dual tDCS applied during motor skill learning effectively enhances both immediate learning and long-term retention in stroke patients.
  • tDCS promotes more efficient neural network engagement, supporting sustained motor function recovery.
  • This study provides insights into the neural substrates of tDCS-mediated motor rehabilitation, highlighting its potential for stroke recovery.