Effect of a double-coated probiotic formulation on functional constipation in the elderly: a randomized, double...

Area of Science:

• Gastroenterology
• Microbiology
• Geriatrics

Background:

• Functional constipation is prevalent in elderly nursing home residents.
• Probiotics are explored as a potential treatment for constipation.

Purpose of the Study:

• To evaluate the efficacy of a multi-species probiotic, Duolac® Care, in elderly individuals with functional constipation.
• To assess the impact of a double-coating technology on probiotic survival and effectiveness.

Main Methods:

• A randomized, double-blind, controlled study involving 40 elderly participants.
• Participants received either double-coated (DC) or non-coated (NC) probiotic capsules twice daily for 2 weeks.
• Fecal bacteria levels and constipation symptoms (Rome III criteria) were analyzed.

Main Results:

• The DC group showed significant improvements in 'effort to evacuate', 'sensation of anorectal obstruction or blockage', and 'defecation frequency'.
• The NC group only improved in 'effort to evacuate'.
• Fecal analysis revealed significantly higher levels of consumed bacteria in the DC group (approx. 100-fold increase) compared to the NC group, indicating enhanced bacterial survival due to the coating.

Conclusions:

• The double-coating technology enhances probiotic survival in the gastrointestinal tract.
• Duolac® Care, with its protective coating, demonstrates potential as an effective treatment option for functional constipation in the elderly.