Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

9.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
9.1K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

4.6K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.6K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

6.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
6.1K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

7.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.5K
Vitamins01:30

Vitamins

3.2K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the potential of Eu<sup>3+</sup> and Mn<sup>4+</sup> activated LaAlO<sub>3</sub> phosphors as red and far-red emitters for horticulture lighting.

RSC advances·2023
Same author

[Laser YAG iris cystotomy].

Journal francais d'ophtalmologie·2023
Same author

Challenges in measuring energy balance and body composition.

European journal of clinical nutrition·2023
Same author

Assessment of job satisfaction, lifestyle behaviors, and occupational burnout symptoms during the COVID-19 pandemic among radiologic technologists in Saudi Arabia.

Radiography (London, England : 1995)·2022
Same author

Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental mapping.

Journal of analytical atomic spectrometry·2021
Same author

Response to Letter from Bero et al.

European journal of clinical nutrition·2019
Same journal

Interpreting maternal and neonatal outcomes in COVID-19-affected pregnancies.

The Indian journal of medical research·2026
Same journal

Incorporating patient- and caregiver-derived needs into national cancer research priority setting in India.

The Indian journal of medical research·2026
Same journal

Advances in glioblastoma: Is there light at the end of the tunnel?

The Indian journal of medical research·2026
Same journal

Authors' response.

The Indian journal of medical research·2026
Same journal

Formulation and sensory evaluation of nutrient-dense complementary food mixes for infants and young children aligned with national nutritional standards in India: A D-optimal mixture design approach.

The Indian journal of medical research·2026
Same journal

Prevalence of hypothyroidism among pregnant women and associated feto-maternal outcomes in India: Systematic review and meta-analysis.

The Indian journal of medical research·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

19.1K

Vitamin D & endothelial function.

A Alyami, M J Soares1, J L Sherriff

  • 1Directorate of Nutrition, Dietetics & Food Technology, School of Public Health, Curtin University, Perth, Australia.

The Indian Journal of Medical Research
|December 10, 2014
PubMed
Summary
This summary is machine-generated.

Vitamin D supplementation did not consistently improve endothelial function in recent trials. Further research is needed to determine if higher vitamin D levels or longer intervention periods benefit vascular health.

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

28.2K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

19.1K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

28.2K
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

44.7K

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to obesity, cardiovascular disease (CVD), and type 2 diabetes.
  • Endothelial dysfunction is a potential mechanism underlying insulin resistance and CVD risk.
  • Extra-skeletal roles of vitamin D are gaining research interest.

Purpose of the Study:

  • To review recent randomized controlled trials (RCTs) investigating the causal link between vitamin D supplementation and endothelial function.
  • To assess the impact of vitamin D on vascular reactivity and markers of inflammation.

Main Methods:

  • PubMed search (2009-present) for RCTs on vitamin D supplementation and direct endothelial function measures.
  • Inclusion criteria: English language, Jadad score ≥ 3.
  • Ten high-quality RCTs were selected and their outcomes summarized.

Main Results:

  • Only two studies demonstrated improved flow-mediated dilation with vitamin D supplementation.
  • Three studies reported reductions in specific inflammatory markers (C-reactive protein, PAI-1, t-PA, BNP).
  • Overall, recent high-quality RCTs did not support a beneficial effect of vitamin D on vascular reactivity.

Conclusions:

  • Current evidence from rigorous RCTs does not confirm vitamin D's benefit for endothelial function.
  • Future studies should explore higher vitamin D dosages and longer intervention durations.
  • The potential regulatory role of vitamin D in endothelial function requires further investigation.