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A new approach to estimating weight change and its reference intervals during the first 96 hours of life

M J Fonseca1,2, M Severo1,2, A C Santos1,2

  • 1EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal.

Acta Paediatrica (Oslo, Norway : 1992)
|December 10, 2014
PubMed

Insights

A new model accurately estimates newborn weight change within the first 96 hours of life. It identified the weight nadir at 52.3 hours, with a mean weight ratio of 0.933.

Area of Science:

  • Neonatal research
  • Pediatric growth monitoring
  • Biostatistics

Background:

  • Accurate tracking of infant weight change is crucial for assessing health and development.
  • Existing methods may lack precision in estimating weight nadir and reference intervals during the early postnatal period.

Purpose of the Study:

  • To apply a novel longitudinal model for estimating weight change and its reference intervals in newborns up to 96 hours of life.
  • To determine the precise time of weight nadir and associated weight loss in term infants.

Main Methods:

  • Utilized data from 1288 full-term singletons in the Generation XXI birth cohort.
  • Employed longitudinal models to analyze birthweight and subsequent anthropometric measurements.
  • Calculated the weight ratio (weight at time t / birthweight) to standardize weight changes.

Main Results:

  • The developed model accurately estimated newborn weight dynamics.
  • The estimated weight nadir occurred at 52.3 hours of life, with a mean weight ratio of 0.933 (218g loss).
  • Reference intervals for weight ratios at 6, 12, 24, and 36 hours were established.

Conclusions:

  • The novel model provides a more accurate estimation of newborn weight change and reference intervals.
  • The study precisely identified the weight nadir at 52.3 hours, offering valuable clinical insights.
Abstract

Keywords:
neonatenewbornreference intervalsweight loss

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