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Diabetic nephropathy in 2014: improved cardiorenal prognosis in diabetic nephropathy
Hans-Henrik Parving1, Peter Rossing2
1Department of Medical Endocrinology, Rigshopsitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Nature Reviews. Nephrology
|December 10, 2014
Insights
Key 2014 diabetic nephropathy studies emphasized albuminuria
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Diabetic nephropathy is a major complication of diabetes.
- Albuminuria is a key indicator of kidney damage and cardiovascular risk in diabetic patients.
Purpose of the Study:
- To review significant 2014 findings in diabetic nephropathy research.
- To assess the role of albuminuria in predicting complications.
- To evaluate emerging treatments like atrasentan and bardoxolone methyl.
Main Methods:
- Literature review of key 2014 studies.
- Analysis of data on albuminuria as a cardiovascular risk predictor.
- Evaluation of clinical trial outcomes for atrasentan and bardoxolone methyl.
Main Results:
- Albuminuria confirmed as a significant predictor of cardiovascular risk.
- Decreasing incidence of renal and cardiovascular complications noted.
- Atrasentan demonstrated promising efficacy.
- Bardoxolone methyl trial raised safety concerns.
Conclusions:
- Continued focus on albuminuria is crucial for managing diabetic nephropathy.
- Atrasentan shows potential as a therapeutic option.
- Safety issues necessitate caution with bardoxolone methyl.
Abstract:
In 2014, key studies in the field of diabetic nephropathy highlighted the importance of albuminuria as a predictor of cardiovascular risk and showed that the incidence of renal and cardiovascular complications is decreasing. Promising efficacy data were obtained with atrasentan, whereas a trial of bardoxolone methyl led to safety concerns.
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