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The association between coronary slow flow and platelet distribution width among patients with stable angina pectoris

Ferhat Ozyurtlu1, Veysel Yavuz2, Nurullah Cetin3

  • 1Special Grand Medical Hospital, Manisa, Turkey.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|December 10, 2014
PubMed

Insights

Platelet distribution width (PDW) and hemoglobin (Hb) levels are significantly elevated in patients with coronary slow flow (CSF). Higher PDW and Hb may predict the presence of CSF, warranting further investigation.

Area of Science:

  • Cardiology
  • Hematology
  • Diagnostic markers

Background:

  • Coronary slow flow (CSF) is an angiographic finding characterized by delayed distal vessel opacification without significant epicardial stenosis.
  • Increased thrombogenic activity and inflammation are implicated in CSF pathophysiology.

Purpose of the Study:

  • To investigate the association between platelet distribution width (PDW) and coronary slow flow (CSF).

Main Methods:

  • A case-control study involving 136 patients with CSF and 152 controls with normal coronary angiograms.
  • Evaluation of laboratory parameters, including PDW, neutrophil lymphocyte ratio (NLR), hemoglobin (Hb), and red cell distribution width (RDW).

Main Results:

  • PDW, NLR, Hb, and RDW were significantly higher in the CSF group compared to the control group.
  • PDW > 16.15 and Hb > 13.75 were identified as predictors of CSF with 83% and 73% sensitivity, respectively.

Conclusions:

  • PDW, Hb, NLR, and RDW are significantly elevated in patients with CSF compared to those with normal coronary flow.
  • Further research is recommended to elucidate the specific roles of PDW and Hb in CSF.
Abstract

Keywords:
coronary slow flowplatelet distribution width

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