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The relationship between vitamin D deficiency and coronary artery ectasia
Mehmet Demir1, Canan Demir2, Serdar Keçeoğlu1
1Cardiology Department, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.
Insights
Patients with coronary artery ectasia (CAE) have significantly lower vitamin D levels and higher parathormone (PTH) levels compared to controls. This study suggests a link between vitamin D deficiency and CAE, highlighting potential implications for cardiovascular health.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- The exact causes of coronary artery ectasia (CAE) remain unclear, despite associations with arteritis, endothelial dysfunction, and atherothrombosis.
- Vitamin D deficiency is implicated in various cardiovascular conditions, including coronary artery disease, heart failure, and hypertension.
- Vitamin D deficiency may influence cardiovascular health by activating the renin-angiotensin-aldosterone system.
Purpose of the Study:
- To investigate the relationship between vitamin D levels and coronary artery ectasia (CAE).
- To compare serum 25-hydroxy vitamin D (25-OH vitamin D) levels in patients with CAE versus a control group.
Main Methods:
- A case-control study involving 50 patients diagnosed with CAE and 30 healthy controls.
- Measurement of serum 25-OH vitamin D and parathormone (PTH) levels in all participants.
- Statistical comparison of vitamin D and PTH levels between the CAE patient group and the control group.
Main Results:
- No significant differences in basic demographic characteristics were observed between the groups.
- Patients with CAE exhibited significantly higher average PTH levels compared to controls (97.8 ±46.3 pg/ml vs. 59.1 ±23.7 pg/ml; p < 0.001).
- Patients with CAE had significantly lower average 25-OH vitamin D levels than controls (18.9 ±8.5 ng/ml vs. 31.3 ±11.2 ng/ml; p < 0.001).
Conclusions:
- The study found a significant association between coronary artery ectasia (CAE) and vitamin D deficiency.
- Lower vitamin D levels and higher PTH levels in CAE patients suggest a potential role for vitamin D in the pathophysiology of CAE.
Introduction:
The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. The role of vitamin D deficiency suggests cardiovascular diseases such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For this reason, it could be suggested that there is a relationship between vitamin D deficiency and CAE.
Aim:
We aimed to compare the 25-OH vitamin D levels of CAE patients with those of controls.
Material And Methods:
This study included 50 CAE patients (20 male, mean age: 60.26 ±10.6 years) and 30 controls (10 males, mean age: 57.86 ±11.6 years). Along with routine tests, 25 OH vitamin D and parathormone (PTH) levels were analysed. Twenty-five OH vitamin D and PTH levels were compared.
Results:
No statistically significant difference was found between the two groups in terms of basic characteristics. The average PTH level of the group of patients with CAE was higher than the average PTH level of the controls (97.8 ±46.3 pg/ml vs. 59.1 ±23.7 pg/ml; p < 0.001). The average 25 OH vitamin D level of the group of the patients with CAE was lower than the average 25 OH vitamin D level of the control group (18.9 ±8.5 ng/ml vs. 31.3 ±11.2 ng/ml; p < 0.001).
Conclusions:
An association between CAE and vitamin D deficiency was found in our study.
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