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The effect of vitamin C on endothelial function of children with type 1 diabetes: an experimental study

Mohammad Reza Sabri1, Esfandiar Najafi Tavana2, Alireza Ahmadi1

  • 1Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

International Journal of Preventive Medicine
|December 10, 2014
PubMed

Insights

Vitamin C supplementation may offer a protective effect on endothelial function in children with type 1 diabetes. However, further research is needed to confirm its effectiveness due to the study

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Nutritional Science

Background:

  • Endothelial dysfunction is a critical concern in type 1 diabetes mellitus (DM), contributing to micro- and macro-vascular complications.
  • Improving endothelial function is vital for managing type 1 DM and preventing associated complications.

Purpose of the Study:

  • To investigate the effect of vitamin C administration on endothelial function in children diagnosed with type 1 diabetes.
  • To assess vitamin C's impact on flow-mediated dilatation (FMD) and intima-media thickness (IMT) in pediatric type 1 DM patients.

Main Methods:

  • An analytic-experimental study involving children with type 1 DM (aged 6-18) and a healthy control group.
  • Vitamin C (250 mg/day) was administered for one month to both groups.
  • Endothelial function was assessed using vascular Doppler ultrasonography to measure FMD and IMT before and after the intervention.

Main Results:

  • Intima-media thickness (IMT) decreased significantly in all groups post-vitamin C administration (P < 0.05).
  • Flow-mediated dilatation (FMD) increased in all groups, with a statistically significant improvement observed only in the control group (P = 0.02).
  • No significant differences were found in the changes of IMT, FMD, left ventricular mass, or blood pressure between the diabetic and control groups, or based on glycemic control (HbA1c levels).

Conclusions:

  • Vitamin C may possess a protective role against endothelial dysfunction.
  • The study was underpowered to definitively establish vitamin C's effectiveness in high-risk populations like diabetic patients, necessitating larger sample sizes for conclusive results.
Abstract

Keywords:
Endotheliumtype 1 diabetesvitamin C

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