Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated plasma cortisol levels during interferon-gamma treatment.

E Späth-Schwalbe1, F Porzsolt, W Digel

  • 1Abteilung Innere Medizin I, Universität Ulm, F.R.G.

Immunopharmacology
|May 1, 1989
PubMed
Summary

Interferon-gamma (IFN-gamma) treatment in cancer patients caused a significant increase in cortisol levels, potentially impacting treatment effectiveness. This neuroendocrine response may be linked to fever during therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Study of η^{'}→γπ^{+}π^{-} Decay Dynamics.

Physical review letters·2018
Same author

Determination of the Spin and Parity of the Z_{c}(3900).

Physical review letters·2017
Same author

Observation of ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ.

Physical review letters·2017
Same author

Observation of Λ_{c}^{+}→nK_{S}^{0}π^{+}.

Physical review letters·2017
Same author

Precise Measurement of the e^{+}e^{-}→π^{+}π^{-}J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV.

Physical review letters·2017
Same author

Evidence of Two Resonant Structures in e^{+}e^{-}→π^{+}π^{-}h_{c}.

Physical review letters·2017

Area of Science:

  • Endocrinology
  • Immunology
  • Oncology

Background:

  • Interferon-gamma (IFN-gamma) is used in cancer therapy.
  • The neuroendocrine effects of IFN-gamma are not fully understood.

Purpose of the Study:

  • To investigate the impact of IFN-gamma on cortisol and ACTH levels in patients with advanced metastatic tumors.
  • To explore the relationship between IFN-gamma administration, cortisol response, and fever.

Main Methods:

  • Plasma cortisol and ACTH levels were measured in 9 patients before and during IFN-gamma treatment.
  • Measurements were taken at specific time points after IFN-gamma administration.

Main Results:

  • A sharp rise in plasma cortisol levels was observed 2-4 hours after IFN-gamma administration, coinciding with fever onset.

Related Experiment Videos

  • Peak cortisol levels occurred 4-6 hours post-injection, while IFN-gamma serum levels peaked later (6-10 hours).

    • Conclusions:

    • Elevated cortisol during IFN-gamma treatment may represent a homeostatic response to the immunological stimulus.
    • High cortisol levels induced by IFN-gamma might potentially reduce its in vivo effectiveness in cancer patients.