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Luminal signaling: it's what's on the inside that counts

Jennifer M Symonds1, Matthew P Hoffman1

  • 1Matrix and Morphogenesis Section, NIDCR, NIH, Bethesda, MD 20892, USA.

Developmental Cell
|December 10, 2014
PubMed
Summary

Epithelial cells secrete fibroblast growth factors (FGFs) into a microlumen, creating luminal signaling. This localized signaling coordinates cell differentiation and collective migration during organogenesis.

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