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Updated: Apr 19, 2026
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Monitoring gastric cancer progression with circulating tumour DNA
T Hamakawa1, Y Kukita2, Y Kurokawa3
11] Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2-E2, Yamadaoka, Suita, Osaka 565-0871, Japan [2] Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disease, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan.
Circulating tumour DNA (ctDNA) shows promise for monitoring gastric cancer. TP53-mutated ctDNA levels in plasma correlated with disease status, aiding in tracking progression and residual disease.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genomics
Background:
- Circulating tumour DNA (ctDNA) is an emerging biomarker for various malignancies.
- Gastric cancer monitoring may benefit from ctDNA analysis.
Purpose of the Study:
- To investigate the utility of TP53-mutated ctDNA in monitoring gastric cancer.
- To correlate ctDNA levels with tumour status during the clinical course.
Main Methods:
- Targeted deep sequencing of plasma cell-free DNA (cfDNA) was performed.
- Massively parallel sequencing was used for patients with TP53-mutated tumours.
- Quantitative TP53-ctDNA values were compared with tumour status.
Main Results:
- TP53 mutations were detected in preoperative cfDNA in 3 out of 10 patients with primary tumours.
- cfDNA concentrations did not consistently reflect disease course.
- The ctDNA fraction demonstrated a correlation with the disease status.
Conclusions:
- ctDNA can serve as a valuable biomarker for monitoring gastric cancer.
- ctDNA analysis may aid in tracking disease progression and residual disease detection.
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