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Updated: Apr 19, 2026

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
Published on: April 18, 2025
Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially
J Quanico1, J Franck, J P Gimeno
1Laboratoire PRISM: Protéomique, Réponse Inflammatoire, Spectrométrie de masse, INSERM, Université de Lille 1, Bât. SN3, 1er étage, F-59655 Villeneuve D'Ascq, France. isabelle.fournier@univ-lille1.fr.
Abstract:
Mass spectrometry-based methods for prostate cancer biomarker discovery are hampered by their low-throughput capabilities because of extensive sample preparation. We present the parafilm-assisted microdissection technique coupled with label-free quantification and bioinformatics analysis as a means to evaluate directly protein expression changes on benign and tumor regions.
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