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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: Apr 19, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Large area CMOS bio-pixel array for compact high sensitive multiplex biosensing.

Laure Sandeau¹, Cassandre Vuillaume, Sylvain Contié

¹PixinBio SAS, 100 Route de Houilleres, 13590 Meyreuil, France.

|December 11, 2014

Summary

This summary is machine-generated.

This study presents a novel CMOS bio-pixel array for sensitive, multiplex cytokine detection. The integrated sensor achieves single-digit pg/mL sensitivity, enabling compact and efficient bioassays.

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Area of Science:

Biomedical Engineering
Photonics
Biosensing Technology

Background:

Multiplexed detection of cytokines is crucial for understanding biological processes and disease.
Existing biosensing platforms often face limitations in sensitivity, compactness, and multiplexing capability.
Integrated assay substrates and readout systems are needed for simplified and efficient bioassays.

Purpose of the Study:

To demonstrate a novel CMOS bio-pixel array for multiplex and multireplicate detection of cytokines.
To achieve high sensitivity (single-digit pg/mL) in cytokine detection using the developed bio-pixel array.
To showcase a compact sensor and reader format by integrating assay substrate and readout on-chip.

Main Methods:

Development of a novel CMOS bio-pixel array with integrated assay substrate and readout.
Utilization of uniquely designed large area bio-pixels for individual assay addressing.
Implementation of chemiluminescent assays directly on the pixel surface for photon detection.
Leveraging the high refractive index of silicon-based pixels to enhance luminescence response.

Main Results:

Demonstration of multiplex and multireplicate detection of three cytokines.
Achieved single-digit pg/mL sensitivity for cytokine detection.
Successful integration of assay substrate and readout in a compact format.
Enhanced photon collection efficiency due to supercritical angle luminescence response.

Conclusions:

The novel CMOS bio-pixel array offers a highly sensitive and compact platform for multiplex cytokine detection.
The integrated design and enhanced photon collection significantly improve biosensing performance.
This technology holds promise for advanced diagnostics and biological research requiring sensitive biomarker quantification.