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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
33.6K
Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Use of Human Perivascular Stem Cells for Bone Regeneration
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Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

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Stem cells for reutilization in bone regeneration.

Gun-Il Im1

  • 1Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Korea.

Journal of Cellular Biochemistry
|December 11, 2014
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for bone regeneration in critical-sized defects, offering an alternative to limited autologous bone grafts. Further assessment is needed to establish stem cell therapy as a standard treatment for bone repair.

Keywords:
BONE DEFECTSBONE REGENERATIONOSTEONECROSIS OF FEMORAL HEADREUTILIZATIONSTEM CELLS

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Bone defects, especially critical-sized ones, present significant clinical challenges.
  • Autologous bone grafting is the gold standard but faces limitations due to donor site morbidity and limited availability.
  • Novel therapeutic strategies are required for effective bone regeneration.

Purpose of the Study:

  • To review current stem cell sources investigated for bone regeneration.
  • To assess the status of stem cell reutilization in treating bone defects.
  • To discuss future perspectives for stem cell therapy in bone repair.

Main Methods:

  • Literature review of studies investigating stem cells for bone regeneration.
  • Analysis of different stem cell sources and their applications.
  • Evaluation of the efficacy and limitations of current stem cell therapies.

Main Results:

  • Various stem cell sources have been explored for their osteogenic potential.
  • Individual studies report successful outcomes, but stem cell therapy is not yet standardized.
  • Challenges remain in optimizing delivery, integration, and long-term efficacy.

Conclusions:

  • Stem cell therapy holds potential for regenerating bone in critical defects.
  • Further research and clinical assessment are necessary to establish stem cell therapy as a reliable treatment.
  • Future directions include optimizing cell sources and delivery methods for enhanced bone regeneration.