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Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Gastroesophageal Reflux Disease01:25

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Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
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Chronic Pharyngitis01:23

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
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It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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Esophageal Strictures-II: Clinical Features and Management01:26

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Acute Pharyngitis01:30

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Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

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Current perspectives on reflux laryngitis.

Daisuke Asaoka1, Akihito Nagahara, Kenshi Matsumoto

  • 1Department of Gastroenterology, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan, daisuke@juntendo.ac.jp.

Clinical Journal of Gastroenterology
|December 11, 2014
PubMed
Summary
This summary is machine-generated.

Laryngopharyngeal reflux (LPR), a GERD complication, lacks clear diagnostics. Research is ongoing to understand LPR pathophysiology and improve reflux laryngitis diagnosis and treatment.

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Area of Science:

  • Gastroenterology
  • Otolaryngology

Background:

  • Laryngopharyngeal reflux (LPR) is an extraesophageal manifestation of gastroesophageal reflux disease (GERD).
  • The increasing prevalence of GERD highlights the significance of LPR.
  • However, LPR pathophysiology remains incompletely understood, and diagnostic criteria are debated.

Purpose of the Study:

  • To review the current understanding of Laryngopharyngeal reflux (LPR).
  • To discuss the challenges in diagnosing reflux laryngitis.
  • To explore recent advancements and future research directions in LPR.

Main Methods:

  • Literature review of LPR pathophysiology and diagnosis.
  • Discussion of an experimental animal model for reflux laryngitis.
  • Evaluation of current diagnostic and therapeutic approaches for LPR.

Main Results:

  • A definitive gold standard diagnostic test for reflux laryngitis is currently unavailable.
  • An experimental animal model has been developed to study reflux laryngitis pathophysiology.
  • Empirical treatment with lifestyle changes and proton pump inhibitors is a common approach.

Conclusions:

  • Effective diagnosis and management of LPR remain challenging.
  • Multichannel intraluminal impedance and pH monitoring is the best available tool for detecting nonacid reflux.
  • Further prospective, evidence-based research is crucial for advancing LPR understanding and patient care.