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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Preparation and Characterization of SDF-1&#945;-Chitosan-Dextran Sulfate Nanoparticles
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Chitosan/dextran multilayer microcapsules for polyphenol co-delivery.

Marco Paini1, Bahar Aliakbarian1, Alessandro A Casazza1

  • 1Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.

Materials Science & Engineering. C, Materials for Biological Applications
|December 11, 2014
PubMed
Summary
This summary is machine-generated.

Polysaccharide microcapsules were developed for controlled polyphenol release. These nanostructured capsules efficiently encapsulate and release low water-soluble compounds like polyphenols under acidic conditions.

Keywords:
Acidic environmentControlled releaseLayer-by-layerNanostructured polymeric capsulesPolyphenols

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Polyphenols are valuable compounds with low water solubility, posing challenges for effective delivery.
  • Controlled release systems are crucial for optimizing the bioavailability and therapeutic efficacy of such compounds.

Purpose of the Study:

  • To fabricate polysaccharide-based nanostructured polymeric microcapsules for encapsulating and controlling the release of polyphenols.
  • To investigate the encapsulation efficiency and release kinetics of polyphenols from these microcapsules.

Main Methods:

  • Fabrication of dextran/chitosan multilayer microcapsules using electrostatic layer-by-layer self-assembly.
  • Monitoring fabrication with quartz crystal microbalance with dissipation monitoring (QCM-D).
  • Characterization of morphology via scanning electron microscopy (SEM) and encapsulation/release via UV spectroscopy and High-Performance Liquid Chromatography (HPLC).

Main Results:

  • Optimized encapsulation achieved with a 35:65 ethanol:water solution, yielding a loading efficiency of 42.0±0.6%.
  • Controlled release of 11.5±0.7 mg of total polyphenols per 11.3 μL of microcapsules over 240 minutes in an acidic environment.
  • Demonstrated reversible permeability variation of the capsule shell for polyphenol loading.

Conclusions:

  • Polysaccharide-based nanostructured microcapsules are effective for encapsulating and controlling the release of low water-soluble molecules, including polyphenols.
  • The layer-by-layer self-assembly technique provides a viable method for creating functional microcapsules for drug delivery applications.