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Effect of low voltage AC fields on cardiovascular implants.

Anjana Kothandaraman1, Tony Anson1, Alan Reynolds1

  • 1Brunel University, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.

Materials Science & Engineering. C, Materials for Biological Applications
|December 11, 2014
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Summary

This study investigated the effect of electric fields on coronary artery stent mimics, finding that specific voltages influence red blood cell (RBC) adhesion. Controlling RBC adhesion could prevent thrombus formation and potentially aid cancer therapy.

Keywords:
ACBMSCardiovascularDESElectric fieldEndothelial cellImplantsLate Stent ThrombosisRed blood cellRestenosisStent

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Electrical Engineering

Background:

  • Coronary artery stents are preferred for vascular occlusive disease over bypass surgery due to minimally invasive procedures, faster recovery, and lower costs.
  • Understanding cellular responses to materials used in medical devices is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the cellular response, specifically red blood cell (RBC) adhesion, to type 316LM Stainless Steel stent mimics when subjected to an AC electric field.
  • To explore the potential clinical implications of controlling RBC adhesion using electric fields.

Main Methods:

  • Type 316LM Stainless Steel stent mimics were exposed to varying AC electric field voltages.
  • Red blood cell (RBC) adhesion to the stent surface was quantified at different voltage levels.
  • Microscopic analysis was performed to observe RBC behavior and alignment.

Main Results:

  • The highest RBC adhesion occurred at voltages above 88 mV and below 74 mV.
  • A unique alignment of RBCs along fracture lines on the stent surface was observed at 88 mV, attributed to increased local electrical conductivity.
  • The study demonstrated that electric fields can influence RBC adhesion patterns on stent surfaces.

Conclusions:

  • Controlling RBC adhesion via electric fields presents potential clinical applications, including the inhibition of thrombus formation.
  • This research provides a foundation for exploring the application of electric fields in cancer therapy, building upon observed cellular responses.