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Off-Label Antipsychotic Withdrawal in People With Intellectual Disabilities: Development and Internal Validation of a Prediction Model.

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Effects of positive behaviour support delivered by direct staff on challenging behaviours and quality of life of adults with intellectual disabilities: A multicentre cluster-controlled trial.

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Related Experiment Video

Updated: Apr 19, 2026

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
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[Challenging behaviour in patients with intellectual disability].

Gerda M de Kuijper1, P Vrijmoeth

  • 1GGZ Drenthe, Centrum verstandelijke beperking en psychiatrie, Assen.

Nederlands Tijdschrift Voor Geneeskunde
|December 11, 2014
PubMed
Summary

Multidisciplinary assessment is crucial for diagnosing and treating challenging behaviors in individuals with intellectual disabilities. Addressing physical, psychological, and environmental factors leads to improved patient outcomes.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Intellectual Disability Research

Background:

  • Challenging behaviors in individuals with intellectual disabilities (ID) can stem from complex physical, psychological, and environmental factors.
  • Effective diagnosis and treatment necessitate a comprehensive, multidisciplinary approach.

Observation:

  • Case 1: A 48-year-old man with mild ID exhibited cognitive decline and aggression, diagnosed as a mood disorder; treatment with psychotropic drugs and psychotherapy improved functioning.
  • Case 2: A 10-year-old girl with moderate ID presented with temper tantrums attributed to environmental factors; parental support and education resolved the behavior.
  • Case 3: A 61-year-old woman with Down syndrome and Alzheimer's dementia showed agitation and resistance to care, initially treated with psychotropics. Further examination revealed physical causes (collapsed vertebrae, osteoporosis) contributing to her distress.

Findings:

  • The case studies highlight the diverse origins of challenging behaviors in intellectual disability.
  • Psychiatric diagnoses and treatments were effective in some cases, while environmental or underlying physical conditions required different interventions.
  • A thorough, individualized assessment is paramount for accurate diagnosis and successful treatment planning.

Implications:

  • These findings underscore the importance of integrated care models for individuals with intellectual disabilities.
  • Healthcare professionals should consider a broad range of potential causes, including physical comorbidities, when evaluating challenging behaviors.
  • Tailored interventions, informed by multidisciplinary assessments, are essential for enhancing the quality of life for individuals with intellectual disabilities.