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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Crohn's Disease01:25

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Psoriasis concurrent with inflammatory bowel disease.

H S Park, S J Koh, G Y Park

    Journal of the European Academy of Dermatology and Venereology : JEADV
    |December 11, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Psoriasis concurrent with inflammatory bowel disease (IBD) in Asian patients presents with increased severity and higher risks of psoriatic arthritis and autoimmune comorbidities. Further research is needed to understand the underlying causes.

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    Area of Science:

    • Dermatology
    • Gastroenterology
    • Immunology

    Background:

    • Psoriasis and inflammatory bowel disease (IBD) association is known, but data on their concurrence in Asian populations is limited.
    • Previous studies suggest higher morbidities in Caucasian populations with concurrent psoriasis and IBD.

    Purpose of the Study:

    • To analyze the characteristics of psoriasis concurrent with IBD in Asian patients.
    • To investigate the associated morbidity in this patient group.

    Main Methods:

    • Retrospective analysis of 15 patients diagnosed with both psoriasis and IBD.
    • Comparison with 60 age-, gender-, and ethnicity-matched controls with psoriasis only.
    • Data collected from Seoul National University Hospital and Seoul National University Boramae Hospital (1990-2012).

    Main Results:

    • Patients with concurrent psoriasis and IBD showed higher erythrocyte sedimentation rate and C-reactive protein levels.
    • A greater proportion of cases had psoriatic arthritis and multiple autoimmune diseases.
    • While trends for younger onset, longer duration, and higher PASI scores were observed, they were not statistically significant.

    Conclusions:

    • Asian patients with concurrent psoriasis and IBD exhibit distinct characteristics, including increased psoriasis severity, higher risk of psoriatic arthritis, elevated systemic inflammation, and more autoimmune comorbidities.
    • Further research with larger cohorts is necessary to elucidate the exact pathogenesis.