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The CBS/CSE system: a potential therapeutic target in NAFLD?
Lindsei K Sarna1, Yaw L Siow, Karmin O
1a Laboratory of Integrative Biology, St. Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.
Canadian Journal of Physiology and Pharmacology
|December 11, 2014
Summary
The cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) system is a potential therapeutic target for non-alcoholic fatty liver disease (NAFLD). Its dysregulation is linked to NAFLD and associated conditions like obesity and diabetes.
Area of Science:
- Hepatology
- Biochemistry
- Metabolic Disorders
Background:
- Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver condition with complex, poorly understood pathogenesis.
- NAFLD is increasing globally, necessitating novel therapeutic strategies.
- The cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) system is crucial for homocysteine and cysteine metabolism, influencing hydrogen sulfide (H2S) production.
Purpose of the Study:
- To review the role of the hepatic CBS/CSE system in NAFLD.
- To evaluate the CBS/CSE system as a potential therapeutic target for NAFLD.
- To explore the links between CBS/CSE system dysregulation and NAFLD pathogenesis.
Main Methods:
- Literature review focusing on the hepatic CBS/CSE system.
- Analysis of studies investigating CBS/CSE system activity in NAFLD.
- Examination of the relationship between CBS/CSE system and NAFLD-related molecular mediators.
Main Results:
- The CBS/CSE system is highly expressed and active in the liver.
- Dysregulation of the CBS/CSE system, indicated by altered homocysteine and H2S levels, is observed in NAFLD patients.
- CBS/CSE system dysfunction is implicated in NAFLD and associated comorbidities like obesity and type 2 diabetes.
Conclusions:
- The hepatic CBS/CSE system plays a significant role in NAFLD pathogenesis.
- Targeting the CBS/CSE system offers a promising new avenue for NAFLD management.
- Further research into the CBS/CSE system will enhance understanding and treatment of NAFLD.
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