Related Experiment Video
Updated: Apr 19, 2026
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.8K
Chronic recurrent multifocal osteomyelitis and inflammatory bowel disease
Grace K Audu1, Kornilia Nikaki, Daniel Crespi
1*Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, London †Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Bristol ‡Department of Paediatric Gastroenterology, Royal Free Hospital, London, UK.
Journal of Pediatric Gastroenterology and Nutrition
|December 11, 2014
Summary
Chronic recurrent multifocal osteomyelitis (CRMO) is linked to inflammatory bowel disease (IBD), primarily in children. This study confirms CRMO as a rare extraintestinal complication of IBD, enhancing understanding of the disease course.
Area of Science:
- Pediatric Rheumatology
- Pediatric Gastroenterology
- Inflammatory Diseases
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone condition.
- CRMO has been infrequently associated with inflammatory bowel disease (IBD), predominantly in pediatric populations.
- Understanding the link between CRMO and IBD is crucial for comprehensive patient management.
Observation:
- This study details the UK pediatric experience with CRMO and IBD over 10 years.
- Three new cases of CRMO in children with IBD were identified in the UK.
- Global literature review identified 24 previously reported cases, with 15 in children.
Findings:
- The UK data adds to the global evidence supporting a genuine association between CRMO and IBD in children.
- The findings contribute to a better understanding of the clinical course and presentation of CRMO in IBD patients.
- CRMO should be recognized as a potential rare extraintestinal manifestation of IBD.
Implications:
- Clinicians should consider CRMO in the differential diagnosis of bone pain in children with IBD.
- Early recognition and management of CRMO may improve outcomes for pediatric IBD patients.
- Further research into the pathogenesis of CRMO in IBD is warranted.
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
963
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
963
01:25Inflammatory Bowel Disease III: Crohn's Disease
16
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
16
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
16
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
16
01:26Inflammatory Bowel Disease I: Introduction
20
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
20
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
19
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
19