Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<sup>18</sup>F-PSMA-1007 PET/CT Demonstrates Higher Accuracy for Biochemically Recurrent Prostate Cancer Compared to Contemporary Conventional Imaging.

Advances in urology·2026
Same author

Clinical and genetic characteristics of head and neck paragangliomas from China featuring Sino-European comparisons.

Journal of the Endocrine Society·2026
Same author

Neuroendocrine tumour morphology and platelet derived growth factor receptor alpha expression.

Experimental and molecular pathology·2026
Same author

Is Thiourea the Weak Link? An Investigation of the In Vitro and In Vivo Destabilization of [<sup>203</sup>Pb]- and [<sup>212</sup>Pb]Pb<sup>2+</sup> Thiourea-Based Bioconjugates.

ACS bio & med chem Au·2026
Same author

Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapy.

Bioorganic chemistry·2026
Same author

<sup>68</sup>Ga-Labeled Peptides Targeting Oxytocin Receptor in Breast Cancer Using Linchpin Chemistry for Tandem Peptide Cyclization and Radiometal Chelator Incorporation.

Bioconjugate chemistry·2025

Related Experiment Video

Updated: Apr 19, 2026

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
08:33

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Published on: June 28, 2011

13.4K

18F-Labeled Peptides: The Future Is Bright.

Susan Richter1, Frank Wuest2

  • 1Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada. srichter@ualberta.ca.

Molecules (Basel, Switzerland)
|December 11, 2014
PubMed
Summary

Fluorine-18 (18F)-labeled peptides offer advantages for molecular imaging and therapy. This review covers chemical strategies and technological advances for 18F-peptide labeling, addressing challenges in this growing field.

More Related Videos

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

2.1K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

8.2K

Related Experiment Videos

Last Updated: Apr 19, 2026

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
08:33

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Published on: June 28, 2011

13.4K
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

2.1K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

8.2K

Area of Science:

  • Nuclear medicine
  • Radiopharmaceutical chemistry
  • Peptide chemistry

Background:

  • Radiolabeled peptides are crucial for targeted diagnostic imaging and radiotherapy.
  • Peptides offer advantages like rapid clearance, good tissue penetration, and low immunogenicity.
  • Challenges include metabolic instability and difficulties in labeling, particularly with Fluorine-18 (18F).

Approach:

  • This review examines chemical strategies for 18F-labeling of peptides.
  • It discusses recent technological advancements, including microfluidic technology and automation.
  • The focus is on developing kit-like preparations for 18F-labeled peptides.

Key Points:

  • 18F offers advantages such as high specific activity and favorable physical properties (low beta+ energy, suitable half-life).
  • Despite advantages, 18F-labeling of peptides presents unique challenges.
  • Technological innovations are crucial for efficient and practical 18F-peptide synthesis.

Conclusions:

  • 18F-labeled peptides are a rapidly developing area in molecular imaging and therapy.
  • Advances in labeling strategies and technology are essential to overcome current limitations.
  • The development of automated and kit-based methods will facilitate wider clinical application.