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Correlation between C-reactive protein in peripheral vein and coronary sinus in stable and unstable angina

Weverton Ferreira Leite1, José Antonio Franchini Ramires1, Luiz Felipe Pinho Moreira1

  • 1Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Arquivos Brasileiros De Cardiologia
|December 11, 2014
PubMed

Insights

Peripheral and central high sensitivity C-reactive protein (hs-CRP) levels strongly correlate in patients with coronary artery disease (CAD). This finding supports using peripheral hs-CRP measurements for assessing cardiovascular risk in stable and unstable angina patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • High sensitivity C-reactive protein (hs-CRP) is a key biomarker for cardiovascular risk assessment.
  • A direct correlation between peripheral and central hs-CRP levels has not been previously established.
  • Understanding this relationship is crucial for accurate risk stratification in coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the correlation between hs-CRP levels in peripheral blood (left forearm vein - LFPV) and central blood (coronary sinus - CS).
  • To assess this correlation in patients diagnosed with stable angina (SA) or unstable angina (UA).

Main Methods:

  • An observational, descriptive, cross-sectional study design was employed.
  • Blood samples were collected from LFPV and CS in 40 CAD patients prior to coronary angiography.
  • Patients were categorized into SA (n=20) and UA (n=20) groups.

Main Results:

  • A strong linear correlation was observed between LFPV and CS hs-CRP levels.
  • This correlation was significant for both SA (r = 0.993, p < 0.001) and UA (r = 0.976, p < 0.001) subgroups.
  • The overall sample demonstrated a robust linear correlation (r = 0.985, p < 0.001).

Conclusions:

  • Peripheral hs-CRP levels reliably reflect central hs-CRP levels in patients with CAD.
  • The findings support the clinical utility of peripheral hs-CRP measurements for cardiovascular risk assessment in SA and UA.
  • This correlation simplifies monitoring and management of cardiovascular health.
Abstract

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