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Related Experiment Video

Updated: Apr 19, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Structure, dynamics, assembly, and evolution of protein complexes.

Joseph A Marsh1, Sarah A Teichmann

  • 1Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;

Annual Review of Biochemistry
|December 11, 2014
PubMed
Summary
This summary is machine-generated.

Protein complex assembly is crucial for life. Research now integrates structural dynamics and evolutionary mechanisms, revealing how protein complexes form, function, and evolve over time.

Keywords:
heteromerhomomermultimeroligomerprotein interactionsquaternary structureself-assembly

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Area of Science:

  • Structural Biology
  • Molecular Evolution
  • Biochemistry

Background:

  • Protein complex assembly is fundamental to biological processes.
  • Thousands of protein complex structures have been determined, advancing understanding of quaternary structure organization.
  • The study of protein complexes has evolved from static to dynamic representations.

Purpose of the Study:

  • To review advances in understanding protein complex structure, dynamics, and evolution.
  • To explore the principles governing symmetric and asymmetric quaternary structure.
  • To elucidate mechanisms driving the evolution of protein quaternary structure.

Main Methods:

  • Analysis of determined protein complex structures.
  • Integration of structural data with dynamic aspects (conformational changes, assembly pathways, fluctuations).
  • Reconstruction of evolutionary histories and identification of evolutionary mechanisms.

Main Results:

  • Significant progress in understanding protein complex structure and dynamics.
  • Elucidation of how protein complexes evolve through changes in self-assembly or subunit composition.
  • Identification of adaptive and nonadaptive influences on quaternary structure evolution.

Conclusions:

  • Our understanding of protein complexes now encompasses their dynamic nature and evolutionary trajectories.
  • Quaternary structure evolution is driven by changes in assembly states and subunit dynamics.
  • Both adaptive and nonadaptive factors shape the evolution of protein complex structures.