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Related Concept Videos

Introduction to Structures01:30

Introduction to Structures

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A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
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Stability of structures01:14

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In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
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Indeterminate Structure01:18

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Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and...
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Structural Protein Function01:56

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Structural Protein Function01:56

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Updated: Apr 19, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Veritas per structuram.

Stephen C Harrison1

  • 1Harvard Medical School, Boston Children's Hospital, and Howard Hughes Medical Institute, Boston, Massachusetts 02115;

Annual Review of Biochemistry
|December 11, 2014
PubMed
Summary
This summary is machine-generated.

Structural biology advanced rapidly from 1963, moving beyond single protein structures to complex viruses. New technologies continually opened new biological questions to 3D structural analysis.

Keywords:
X-ray crystallographyelectron microscopystructural biologyvirus structure

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Area of Science:

  • Molecular biology
  • Structural biology
  • Virology

Background:

  • The early days of molecular biology (circa 1963) had limited protein structural data, with myoglobin as a key early example.
  • The author's scientific journey began with an interest in determining viral structures using X-ray crystallography.

Discussion:

  • The field of protein crystallography evolved into the broader discipline of structural biology over five decades.
  • The author consistently embraced emerging technologies to apply three-dimensional structural analysis to diverse biological problems.

Key Insights:

  • The 50-year trajectory of structural biology is marked by technological innovation and expanding biological inquiry.
  • The integration of new technologies has been pivotal in advancing three-dimensional biological structure determination.

Outlook:

  • Continued fascination with structural biology suggests ongoing exploration and discovery.
  • The field is poised for further advancements as new technologies emerge, enabling deeper biological understanding.