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Cholinergic neuromodulation by endothelin in guinea pig ileum
N P Wiklund1, C U Wiklund, A Ohlén
1Department of Physiology, Karolinska Institutet, Stockholm, Sweden.
Neuroscience Letters
|July 3, 1989
Abstract:
The effect of endothelin on cholinergic neuroeffector transmission in guinea pig ileum was investigated. Endothelin was shown to inhibit the nerve-induced contractions and concomitantly to increase the basal muscle tone. Furthermore, endothelin inhibited the nerve-induced release of [3H]acetylcholine whereas the contractile response to exogenous acetylcholine was enhanced. In conclusion, our findings suggest that endothelin is a modulator of cholinergic neuroeffector transmission in guinea pig ileum with possible action via both inhibitory prejunctional and stimulatory postjunctional mechanisms.