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Immunoadsorption therapy in dilated cardiomyopathy

Stephan B Felix1, Daniel Beug, Marcus Dörr

  • 1Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.

Expert Review of Cardiovascular Therapy
|December 16, 2014
PubMed

Insights

Dilated cardiomyopathy treatment may involve removing cardiac autoantibodies via immunoadsorption. This experimental therapy shows promise for improving heart function and reducing inflammation in patients with this heart muscle disease.

Area of Science:

  • Cardiology
  • Immunology
  • Heart Failure Research

Background:

  • Dilated cardiomyopathy involves ventricular enlargement and dysfunction, leading to heart failure.
  • Genetic factors, viral infections, and inflammation contribute to dilated cardiomyopathy.
  • Cardiac autoantibodies from humoral immune system activation are implicated in disease progression.

Purpose of the Study:

  • To investigate the role of cardiac autoantibodies in dilated cardiomyopathy.
  • To evaluate the efficacy of immunoadsorption in treating dilated cardiomyopathy.

Main Methods:

  • Review of experimental and clinical studies on dilated cardiomyopathy.
  • Analysis of outcomes from small open-controlled studies using immunoadsorption.

Main Results:

  • Humoral immune system activation and cardiac autoantibodies are functionally significant in dilated cardiomyopathy.
  • Immunoadsorption demonstrated improvement in cardiac function.
  • Immunoadsorption led to a decrease in myocardial inflammation.

Conclusions:

  • Immunoadsorption is a potential experimental treatment for dilated cardiomyopathy.
  • Further placebo-controlled multicenter studies are required to confirm the efficacy of immunoadsorption therapy.

Keywords:
cardiac antibodiesdilated cardiomyopathyhumoral immune systemimmunoadsorptionimmunomodulationmyocardial inflammation

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