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Quantiferon TB-Gold conversion can predict active tuberculosis development in elderly nursing home residents
Ping-Hsien Tsou1,2, Wei-Chang Huang3,4, Chen-Cheng Huang5
1Division of Chest Medicine, Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu, Taiwan.
Geriatrics & Gerontology International
|December 16, 2014
Summary
Serial QuantiFERON-TB Gold (QFT-G) conversion reliably predicts active tuberculosis (TB) in elderly nursing home residents. Tuberculin skin test (TST) is valuable for excluding TB development in this population.
Area of Science:
- Gerontology
- Infectious Diseases
- Diagnostic Medicine
Background:
- Elderly nursing home residents are susceptible to tuberculosis (TB).
- Reliable prediction and exclusion of active TB are crucial in this vulnerable population.
- Serial testing with QuantiFERON-TB Gold (QFT-G) and tuberculin skin test (TST) may offer insights.
Purpose of the Study:
- To evaluate the reliability of serial QFT-G and TST assays.
- To assess their ability to predict or exclude active TB development in elderly nursing home residents.
- To compare the predictive values of QFT-G conversion and TST results.
Main Methods:
- Prospective observational cohort study of 259 elderly nursing home residents without active TB at baseline.
- Serial QFT-G and TST performed at baseline and 2-year follow-up.
- Monitoring for active TB development over a 5-year period.
Main Results:
- Three participants developed active TB during 5-year follow-up.
- Agreement between QFT-G and TST was 54.13% (ĸ = 0.167).
- QFT-G conversion showed a higher incidence rate ratio (15.8) for TB development compared to TST-positive results; PPV for QFT-G conversion was 25%, while NPV for TST-negative was 100%.
Conclusions:
- Serial QFT-G conversion is a more reliable predictor of active TB in this population.
- Serial TST is a valuable tool for excluding the risk of developing active TB.
- These findings aid in TB management strategies for elderly nursing home residents.
Keywords:
Mycobacterium tuberculosisQuantiferon TB-Gold assayelderlynursing home residentstuberculin skin testMore Related Videos
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