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Updated: Apr 19, 2026
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
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MiRNAs as potential molecular targets in heart failure
Michael G Katz1, Anthony S Fargnoli, Richard D Williams
1Sanger Heart & Vascular Institute, Carolinas HealthCare System, Charlotte, NC, USA.
Future Cardiology
|December 16, 2014
Summary
MicroRNAs (miRNAs) regulate genes post-transcriptionally and are implicated in heart failure. Targeting miRNAs offers a promising therapeutic strategy for heart diseases.
Area of Science:
- Molecular Biology
- Cardiovascular Medicine
- Genetics
Background:
- Heart disease pathogenesis involves altered gene expression.
- MicroRNAs (miRNAs) are key post-transcriptional regulators.
- miRNAs play roles in apoptosis, fibrosis, hypertrophy, and cardiac remodeling.
Purpose of the Study:
- To overview advances in targeting miRNAs for heart failure modulation.
- To highlight miRNA-based therapy potential for cardiovascular diseases.
Main Methods:
- Literature review of genetic data and experimental reports.
- Analysis of miRNA roles in heart failure pathological processes.
Main Results:
- Aberrantly expressed miRNAs significantly impact cardiac insufficiency.
- miRNA modulation affects heart failure phenotypes.
Conclusions:
- miRNA-based therapies show promise for treating heart diseases.
- Identifying signaling pathways is crucial for heart failure progression.
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