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Updated: Apr 19, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
Published on: May 21, 2018
Utilizing diversity-oriented synthesis in antimicrobial drug discovery
Eamon Comer1, Jeremy R Duvall, Maurice duPont Lee
1Therapeutics Platform, Broad Institute of MIT & Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
Abstract:
The development of resistance to existing antimicrobials has created a threat to human health that is not being addressed through our current drug pipeline. Limitations with the use of commercial vendor libraries and natural products have created a need for new types of small molecules to be screened in antimicrobial assays. Diversity oriented synthesis (DOS) is a strategy for the efficient generation of compound collections with a high degree of structural diversity. Diversity-oriented synthesis molecules occupy the middle ground of both complexity and efficiency of synthesis between natural products and commercial libraries. In this review we focus upon the use of diversity-oriented synthesis compound collections for the discovery of new antimicrobial agents.
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