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Updated: Apr 19, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors
Matthieu Bertrand1, Valérie Petit, Ashish Jain
1a INSERM UMRS984 Châtenay-Malabry , France.
Abstract:
The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-derived epithelial cell lines. Modulation of the p62 level regulated the expression of junctional proteins. This effect was dependent on the ubiquitin-associated domain of p62, which stabilized the TGFβ/Smad signaling co-activator Smad4 and the EMT transcription factor Twist. This study highlights a novel function of p62 in a major epithelial phenotypic alteration.
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