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Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in

Su Jin Jeong1, Sang Hoon Han1, Chang Oh Kim1

  • 1Department of Internal Medicine, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Geriatrics & Gerontology International
|December 16, 2014
PubMed

Insights

Human cytomegalovirus (HCMV) antibody levels are linked to hypertension and reduced functional status in elderly Koreans. Higher HCMV immunoglobulin G titers correlate with increased blood pressure and poorer daily living activities.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Cardiovascular Health

Background:

  • Human cytomegalovirus (HCMV) is a common virus with potential long-term health implications.
  • Aging populations are susceptible to chronic conditions like hypertension and functional decline.
  • The specific role of HCMV in elderly health, particularly in Koreans, requires further investigation.

Purpose of the Study:

  • To investigate the association between HCMV antibody status and the prevalence of hypertension.
  • To explore the relationship between HCMV antibody levels and the functional status of elderly individuals.
  • To identify potential links between HCMV infection and cardiovascular and functional health in older adults.

Main Methods:

  • Prospective enrollment of 103 elderly Korean patients (≥65 years).
  • Measurement of CD4+, CD8+ T-lymphocyte counts, and functional status (ADL, IADL).
  • Analysis of HCMV immunoglobulin G (IgG) antibody titers using enzyme-linked fluorescent assay.

Main Results:

  • HCMV IgG antibody titers were independently associated with hypertension in elderly patients (OR 1.023).
  • HCMV antibody levels positively correlated with systolic blood pressure, CD8+ T-lymphocyte count, and instrumental activities of daily living (IADL) scores.
  • HCMV IgG titers were inversely associated with estimated glomerular filtration rate (eGFR).

Conclusions:

  • HCMV infection may play a significant role in the development of essential hypertension among the elderly.
  • HCMV may contribute to decreased functional status and poorer kidney function in older adults.
  • These findings highlight the importance of considering HCMV in the context of age-related health issues.
Abstract

Keywords:
antibodycytomegaloviruselderly patientsfunctional statushypertension

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