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Updated: Apr 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Imaging appearances of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Paul J Foran1, Sara A Hayes1, Donald J Blair1
1Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Objective:
The objective of the study was to describe the imaging appearances of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) on computed tomography (CT).
Materials And Methods:
Electronic medical records were searched for patients with pathology-proven DIPNECH who had a CT available for review. Eleven patients were included.
Results:
The most common finding on CT was small pulmonary nodules which were present in all patients and were multiple (≥5) in 7/11 patients. Other CT findings included mosaic pattern attenuation and bronchial wall thickening/bronchiectasis.
Conclusion:
DIPNECH should be considered as a diagnostic possibility when multiple small pulmonary nodules are identified on CT, particularly if there is an associated carcinoid tumor.
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