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Updated: Apr 19, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
[Impact of lung cancer treatments on renal function]
A-C Toffart1, S Belaiche2, D Moro-Sibilot1
1UM oncologie thoracique, pôle cancérologie médecine aiguë et communautaire, CHU A.-Michallon, BP217, 38043 Grenoble cedex 9, France; Université Grenoble 1, U 823, université J.-Fourier, institut A.-Bonniot, 38706 La Tronche cedex, France.
Introduction:
Renal failure in patients with lung cancer may be multifactorial: related to the patients and their comorbidities, direct tumor compression or the toxicity of cancer treatments and other associated medications. This literature review is intended to describe the state of knowledge regarding the nephrotoxicity of treatments used in thoracic oncology.
Findings:
The majority of chemotherapy treatments are potentially nephrotoxic. Cisplatin and pemetrexed exhibit mainly renal tubular toxicity, while vascular renal impairment is found with gemcitabine and bevacizumab. Cisplatin results in acute renal failure in 30% of patients. Renal protective strategies (compliance with recommendations, limitation of nephrotoxic treatments, hydration, magnesium supplementation) must be employed systematically. Targeted therapies do not require any adjustment of the dosage in case of moderate or severe renal insufficiency but adapting the doses of biphosphonates to renal function is necessary.
Conclusion:
This review highlights the need for monitoring of renal function in patients with lung cancer during treatment with chemotherapy or biphosphonates.
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