Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.8K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.8K
Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression.

Cephalalgia : an international journal of headache·2026
Same author

From bench to bedside: relevant animal models across the migraine attack phases.

The journal of headache and pain·2026
Same author

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug-resistant focal epilepsy.

Epilepsia open·2026
Same author

Visually-induced hemodynamic response and white matter hyperintensities in middle-aged women with ischemic stroke or migraine with aura.

Cephalalgia : an international journal of headache·2026
Same author

Tsunamis hiding in plain sight: spreading depression in clinical neurology.

Nature reviews. Neurology·2026
Same author

Cerebral collateral arteriogenesis and cerebrovascular reserve in aged and diet-induced obese mice after unilateral common carotid occlusion.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.4K

Migraine pathophysiology: lessons from mouse models and human genetics.

Michel D Ferrari1, Roselin R Klever2, Gisela M Terwindt1

  • 1Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands.

The Lancet. Neurology
|December 16, 2014
PubMed
Summary

Migraine genetics reveal pathways influencing brain excitability and susceptibility to cortical spreading depression. This research may lead to new treatments for migraine and related neurological disorders.

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.4K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

10.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.7K

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Migraine is a prevalent, disabling neurological disorder, more common in women, often undertreated.
  • Genome-wide association studies identified 13 migraine-associated variants linked to neurotransmission, synaptic function, pain, vasculature, and metalloproteinases.
  • Rare monogenic forms of migraine involve six genes with larger effect sizes, presenting a spectrum of clinical features.

Purpose of the Study:

  • To investigate the pathogenetic mechanisms of migraine using genetic insights and mouse models.
  • To explore the role of cortical spreading depression (CSD) in migraine pathophysiology and its link to other neurological conditions.
  • To examine the influence of hormonal fluctuations on migraine susceptibility.

Main Methods:

  • Analysis of genome-wide association studies to identify migraine-associated gene variants.
  • Utilizing transgenic mouse models harboring human monogenic migraine gene mutations.
  • Assessing cerebral hyperexcitability, glutamatergic neurotransmission, and cortical spreading depression susceptibility in mouse models.
  • Investigating the impact of hormonal changes on CSD susceptibility in mice.

Main Results:

  • Mouse models exhibited migraine-like features, including increased glutamatergic neurotransmission and enhanced CSD susceptibility.
  • Enhanced CSD susceptibility correlated with increased sensitivity to focal cerebral ischemia; blocking CSD improved stroke outcomes.
  • Female hormone level changes in mice mimicked hormonal effects on migraine activity in patients.
  • Findings confirm a multifactorial basis for migraine.

Conclusions:

  • Genetic variants and CSD susceptibility are key factors in migraine pathophysiology.
  • Targeting CSD may offer prophylactic options for migraine and comorbid disorders like epilepsy, depression, and stroke.
  • Understanding hormonal influences on CSD could lead to sex-specific migraine therapies.