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Updated: Apr 19, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
Published on: March 9, 2017
Enabling plant synthetic biology through genome engineering
Nicholas J Baltes1, Daniel F Voytas1
1Department of Genetics, Cell Biology, and Development, and Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Synthetic biology enables the design of new plant systems for industrial or therapeutic compound production and crop protection. Genome engineering with sequence-specific nucleases offers precise DNA modification control for advancing plant synthetic biology.
Area of Science:
- Plant science
- Synthetic biology
- Genome engineering
Background:
- Synthetic biology aims to engineer novel biological systems, including custom plants and plant cells.
- These engineered systems have applications in producing valuable compounds and enhancing crop resilience against environmental stressors and pathogens.
- Precise genetic modification techniques are crucial for unlocking the full potential of plant synthetic biology.
Purpose of the Study:
- To highlight the potential of genome engineering in advancing plant synthetic biology.
- To discuss the role of sequence-specific nucleases in precise DNA modification within plant cells.
- To explore how targeted genetic alterations can lead to improved plant functions.
Main Methods:
- Leveraging recent advancements in sequence-specific nucleases for genome engineering.
- Applying targeted DNA modification techniques to living plant cells.
- Discussing the integration of genome engineering tools within synthetic biology frameworks.
Main Results:
- Genome engineering provides unprecedented control over the genetic code of plant cells.
- Sequence-specific nucleases enable precise and targeted modifications to plant DNA sequences.
- These advancements bring the precise engineering of plant genomes within reach.
Conclusions:
- Genome engineering offers enormous potential for the field of plant synthetic biology.
- Precise control over DNA sequences is key to designing advanced plant systems.
- The integration of these technologies will drive innovation in plant-based solutions.
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