Related Experiment Video
Updated: Apr 19, 2026
09:29
Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography
Published on: May 19, 2022
2.9K
Deciphering the role of exosomes in tuberculosis
Nicole A Kruh-Garcia1, Lisa M Wolfe2, Karen M Dobos1
1Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Tuberculosis (Edinburgh, Scotland)
|December 16, 2014
Summary
Exosomes, small vesicles from cells, are key in cell communication and disease, especially tuberculosis. Research explores their diagnostic potential and use in developing new vaccines.
Area of Science:
- Cell biology
- Immunology
- Biochemistry
Background:
- Exosomes are microvesicles (40-200 nm) released by cells, initially thought to remove proteins.
- They are distinct from other extracellular vesicles and originate from the endocytic pathway.
- Exosomes are found in all bodily fluids and are increasingly studied for their role in cell communication and immune modulation.
Purpose of the Study:
- To review the role of exosomes in tuberculosis (TB).
- To discuss the translational applications of exosomes in vaccine development.
- To highlight the potential of circulating exosomes as diagnostic biomarkers.
Main Methods:
- Literature review of exosome research.
- Analysis of exosome composition and function in disease.
- Exploration of exosome-based diagnostic and therapeutic strategies.
Main Results:
- Exosomes are implicated in the pathogenesis and immune response to tuberculosis.
- Exosomal content can serve as a biomarker for TB diagnosis.
- Exosomes show promise as a platform for TB vaccine development.
Conclusions:
- Exosomes play a significant role in tuberculosis.
- Circulating exosomes offer a valuable source for TB biomarkers.
- Exosomes represent a promising avenue for novel vaccine strategies against tuberculosis.
Related Concept Videos
01:36Overview of Exosomes
4.0K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
4.0K
01:28Pulmonary Tuberculosis II
2.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.4K
01:29Pulmonary Tuberculosis I
1.6K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.6K
01:28Pulmonary Tuberculosis V
943
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
943
01:31Pulmonary Tuberculosis III
1.6K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.6K
01:26Pulmonary Tuberculosis IV
762
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
762