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Related Concept Videos

Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...
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A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
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Paper - a potential platform in pharmaceutical development.

Yi-Hsun Chen1, Zong-Keng Kuo2, Chao-Min Cheng3

  • 1Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 300, Taiwan; Pharmacokinetic Technology Department, Center of Excellence for Drug Development, Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 300, Taiwan.

Trends in Biotechnology
|December 16, 2014
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Summary
This summary is machine-generated.

This study highlights paper

Keywords:
bioassayclinically based diagnostics in hospitaldiagnosticspaper-based microfluidic devicepoint-of-care diagnosticstranslational medicine

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Area of Science:

  • Biomaterials Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Paper's cellulose fibers enable fluid wicking via capillary action.
  • Paper is an inexpensive, eco-friendly material suitable for diagnostics.
  • Existing paper-based assays include molecular, ELISA, nucleic acid, and cell assays.

Purpose of the Study:

  • To explore paper as a superior diagnostic platform compared to plastics.
  • To investigate paper's utility in drug discovery and in vitro pre-compound screening.
  • To address economic challenges within the pharmaceutical industry using paper-based solutions.

Main Methods:

  • Literature review of paper-based diagnostic applications.
  • Analysis of paper's material properties for fluid handling.
  • Comparative assessment of paper versus plastic platforms for drug discovery.

Main Results:

  • Paper exhibits excellent fluid wicking capabilities for diagnostic applications.
  • Paper-based platforms show promise for cost-effective drug discovery and screening.
  • Paper offers advantages over traditional plastic platforms in specific contexts.

Conclusions:

  • Paper is a versatile and advantageous platform for diagnostics and drug discovery.
  • Paper-based assays can potentially reduce costs in pharmaceutical research.
  • Further development of paper platforms could revolutionize in vitro screening processes.