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Related Concept Videos

Micelles01:30

Micelles

297
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
297
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
144

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Related Experiment Video

Updated: Apr 19, 2026

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

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Eco-friendly aqueous core surface-modified nanocapsules.

C Carbone1, T Musumeci1, M R Lauro2

  • 1Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i Research Centre On Ocular Nanotechnology, University of Catania, Catania, Italy.

Colloids and Surfaces. B, Biointerfaces
|December 16, 2014
PubMed
Summary
This summary is machine-generated.

Positively charged nanocapsules were developed using biocompatible materials and an eco-friendly technique. These nanocapsules show potential for ocular delivery of hydrophilic compounds and gene materials.

Keywords:
Cationic lipidCationic nanoparticlesHybrid nanoparticlesOcular deliveryPLATurbiscan

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Developing effective ocular delivery systems is crucial for treating eye diseases.
  • Polymeric nanocapsules offer potential for controlled drug release and improved bioavailability.
  • Existing methods for nanocapsule preparation can be energy-intensive and utilize harsh chemicals.

Purpose of the Study:

  • To develop positively charged nanocapsules for potential ocular delivery.
  • To investigate the use of polylactic acid (PLA) and various oils/surfactants for nanocapsule formulation.
  • To establish a simple, eco-friendly method for preparing nanocapsules using biocompatible materials.

Main Methods:

  • Utilized a reversed phase inversion temperature (PIT) method to create W/O nanoemulsions.
  • Employed Turbiscan® technology and visual observation to optimize polymer/oil combinations.
  • Constructed pseudoternary phase diagrams to evaluate surfactant influence (Span® 60, Span® 80).
  • Prepared cationic hybrid nanocapsules (NC) with a DDAB coating layer.
  • Characterized nanocapsules using Dynamic Light Scattering (PCS), Differential Scanning Calorimetry (DSC), and Atomic Force Microscopy (AFM).

Main Results:

  • Identified optimal PLA/oil combinations for stable nanocapsule formation.
  • Determined the influence of different surfactants on nanoemulsion stability and phase behavior.
  • Successfully prepared positively charged nanocapsules with desirable physico-chemical and morphological properties.
  • Demonstrated the feasibility of an eco-friendly, low-energy preparation technique.

Conclusions:

  • Positively charged nanocapsules can be effectively prepared using a simple, eco-friendly technique.
  • The developed nanocapsules are suitable for ocular delivery of hydrophilic compounds and gene materials.
  • This approach utilizes biocompatible materials and avoids high mechanical energy input.