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Intratracheal Administration of Dry Powder Formulation in Mice
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In vitro dry powder inhaler formulation performance considerations.

Susanne Ziffels1, Norman L Bemelmans2, Phillip G Durham2

  • 1Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 25599-7571, USA; F. Hoffman-La Roche Ltd, Basel, Switzerland.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 16, 2014
PubMed
Summary
This summary is machine-generated.

Accurately predicting dry powder inhaler (DPI) performance requires measuring drug delivery rate alongside dose and particle size. This new method monitors when the drug is released during inhalation, crucial for understanding lung deposition.

Keywords:
Aerodynamic particle size distributionAerosolsDeliver doseDelivery rateFlow rateIn vitro testingInhalationLungsPressure drop

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Area of Science:

  • Pharmaceutical Sciences
  • Respiratory Drug Delivery
  • Inhalation Technology

Background:

  • Current dry powder inhaler (DPI) formulation evaluation often inadequately simulates lung deposition conditions.
  • Existing methods focus on flow rate and pressure drop, neglecting the timing of drug release relative to airflow initiation.

Purpose of the Study:

  • To develop and validate a method for monitoring the drug delivery rate from DPIs during aerodynamic particle size distribution (APSD) testing.
  • To assess the impact of drug delivery timing on predicting in vivo lung deposition.

Main Methods:

  • A novel light obscuration technique was employed to detect dose delivery during inertial impaction-based APSD sampling.
  • Four distinct albuterol sulfate and budesonide formulations in lactose carriers were tested.

Main Results:

  • The study successfully monitored the rate of drug delivery for different DPI formulations.
  • Observed variations in delivery rate suggest potential impacts on the site of drug deposition within the lungs.

Conclusions:

  • Drug delivery rate is a critical parameter, complementary to delivered dose and APSD, for predicting the in vivo performance of DPIs.
  • Incorporating delivery rate measurement enhances the physiological relevance of DPI testing for lung deposition.