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Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.

W Pan¹, A Q Zhang¹, C L Yue¹

¹State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital,Third Military Medical University,Chongqing,China.

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|December 16, 2014

Summary

This meta-analysis found no strong overall link between interleukin-10 (IL-10) gene variations and sepsis risk. However, specific IL-10 polymorphisms were associated with sepsis susceptibility in Caucasian and Asian populations.

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Area of Science:

Immunogenetics
Molecular Biology
Critical Care Medicine

Background:

Interleukin-10 (IL-10) is a key cytokine involved in immune regulation.
Genetic variations in the IL-10 gene may influence susceptibility to sepsis.
Previous studies on IL-10 polymorphisms and sepsis risk have yielded inconsistent findings.

Purpose of the Study:

To quantitatively assess the association between three common IL-10 polymorphisms (-592C/A, -819C/T, -1082A/G) and sepsis susceptibility.
To clarify the role of IL-10 genetic variations in the context of sepsis risk.

Main Methods:

A comprehensive meta-analysis was conducted.
Literature search performed across major databases: PubMed, Web of Science, and EMBASE.
Inclusion of studies evaluating the association of IL-10 polymorphisms (-592C/A, -819C/T, -1082A/G) with sepsis.

Main Results:

Overall, the three evaluated IL-10 polymorphisms showed no significant association with sepsis risk.
Subgroup analysis revealed an association between the -592C/A polymorphism and sepsis susceptibility in Caucasian populations (A vs. C: OR 0.78, P=0.05; AA+CA vs. CC: OR 0.75, P=0.05).
The -1082A/G polymorphism was associated with sepsis susceptibility in Asian populations (G vs. A: OR 1.41, P=0.03; GG+AG vs. AA: OR 2.11, P=0.03).

Conclusions:

The -592C/A polymorphism in the IL-10 gene is linked to sepsis susceptibility in Caucasians.
The -1082A/G polymorphism in the IL-10 gene is associated with sepsis susceptibility in Asians.
These findings highlight ethnicity-specific genetic influences on sepsis risk related to IL-10.