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Updated: Apr 19, 2026

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
Published on: January 29, 2021
[Progressive multifocal leukoencephalopathy in a patient with multiple myeloma]
Cecilie Balslev Willert1, Frederik Neess Engsig, Helle Wulf Eskildsen
1Dagmarsgade 10, 3. th., 2200 København N. ceciliebwi@gmail.com.
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease in the central nervous system. It is caused by reactivation of John Cunningham-virus and has a grave prognosis. PML occurs most frequently in HIV-patients, but can also be seen in patients with iatrogenic immunodeficiency. Here, we present a patient with multiple myeloma and cardiac amyloidosis who developed PML after receiving treatment with several chemotherapeutics. This case report underlines the importance of bearing PML in mind when immunocompromised patients develop diffuse neurological symptoms.
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