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Risk factors for hepatotoxicity in solid organ transplants recipients being treated for tuberculosis
V Schultz1, C A Marroni2, C S Amorim1
1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Transplantation Proceedings
|December 16, 2014
Summary
High-dose rifampin increases liver toxicity risk in solid organ transplant (SOT) recipients with tuberculosis (TB). Lung transplant patients face higher risks, while kidney transplant recipients show a protective effect against TB-related liver damage.
Area of Science:
- Hepatology
- Transplant Surgery
- Infectious Diseases
Background:
- Tuberculosis (TB) poses significant morbidity and mortality risks for solid organ transplant (SOT) recipients.
- SOT patients have a substantially higher incidence of TB compared to the general population.
Purpose of the Study:
- Evaluate the incidence of hepatotoxicity in SOT recipients undergoing TB treatment.
- Identify risk factors associated with liver toxicity in this patient group.
Main Methods:
- Retrospective cohort study conducted in a Brazilian SOT reference hospital.
- Included SOT recipients treated for TB between 2000 and 2012.
Main Results:
- Hepatotoxicity occurred in 33.3% of the 69 patients studied.
- Independent risk factors for hepatotoxicity included rifampin doses ≥600 mg daily and lung transplantation.
- Kidney transplantation was identified as a protective factor against hepatotoxicity.
Conclusions:
- Rifampin at doses of 600 mg or higher daily is an independent risk factor for liver toxicity in SOT recipients with TB.
- Further investigation into the roles of lung transplantation (risk) and kidney transplantation (protection) is warranted.
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