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Updated: Apr 19, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Quality improvement process in a sickle cell infusion center.
Lauren N Whiteman1, Sophie Lanzkron1, Rosalyn W Stewart2
1Department of Medicine, Johns Hopkins University, Baltimore, Md.
Achieving timely pain relief for sickle cell crisis is crucial. Increasing the nurse-to-patient ratio significantly reduced the time to administer the first pain medication dose.
Area of Science:
- Pain Management
- Hematology
- Healthcare Quality Improvement
Background:
- The American Pain Society guidelines recommend parenteral pain medication for sickle cell crisis within 30 minutes of assessment.
- This study investigated adherence to this standard at a specific sickle cell infusion center.
Purpose of the Study:
- To identify factors influencing the timely administration of pain medication during sickle cell crisis.
- To evaluate the impact of various parameters on achieving the recommended 30-minute treatment goal.
Main Methods:
- Patient care time intervals were recorded.
- Data were collected on variables potentially affecting treatment timeliness.
- Time to first parenteral opiate administration was analyzed using linear regression models.
Main Results:
- The average time from assessment to the first pain medication dose was initially 41 minutes.
- A higher nurse-to-patient ratio was correlated with a reduction in this time interval.
Conclusions:
- The nurse-to-patient ratio emerged as a key modifiable factor in reducing pain medication administration times.
- Optimizing the nurse-to-patient ratio presents a viable strategy for improving adherence to pain management standards in sickle cell crisis care.
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