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3D Kinematic Gait Analysis for Preclinical Studies in Rodents
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Inertial control as novel technique for in vitro gait simulations.

T Natsakis1, J Burg2, G Dereymaeker1

  • 1KU Leuven, Department of Mechanical Engineering, Celestijnenlaan 300c, Box 2419, 2001 Heverlee, Belgium.

Journal of Biomechanics
|December 16, 2014
PubMed
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Inertial control revolutionizes in vitro gait simulations by removing the need for pre-defined forces. This new method accurately reflects surgical intervention effects on vertical ground reaction force (vGRF) in cadaveric models.

Area of Science:

  • Biomechanics
  • Orthopedic Surgery
  • Gait Analysis

Background:

  • In vitro gait simulations are crucial for evaluating surgical interventions.
  • Current methods rely on pre-defined kinetics and kinematics, limiting applicability.
  • This restricts simulations to interventions with measurable in vivo data.

Purpose of the Study:

  • Introduce inertial control for in vitro gait simulations.
  • Eliminate the need for pre-defined vertical ground reaction force (vGRF) setpoints.
  • Enable the study of isolated surgical effects on gait kinetics and kinematics.

Main Methods:

  • Developed and applied inertial control methodology for gait simulations.
  • Conducted simulations on 10 cadaveric specimens.
Keywords:
Control theoryGait simulationsIn vitroTotal ankle prosthesisTriple arthrodesis

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  • Tested three conditions: native ankle, total ankle prosthesis (TAP), and TAP with triple arthrodesis (TAP+TA).

    • Main Results:

    • Validated simulated vGRF against in vivo data from 15 healthy volunteers (R²=0.956, S=1.004) for native ankles.
    • Observed changes in vGRF for TAP and TAP+TA conditions.
    • Demonstrated the method's sensitivity to surgical kinematic constraints.

    Conclusions:

    • Inertial control accurately replicates in vivo kinetic conditions in gait simulations.
    • This methodology allows for the investigation of isolated surgical intervention effects.
    • Enables comprehensive analysis of both kinematic and kinetic changes post-surgery.