Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

650
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
650
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Diabetic Nephropathy01:28

Diabetic Nephropathy

2
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
2
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.3K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.3K
Nephrons01:10

Nephrons

9.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.9K
Renal Corpuscle01:20

Renal Corpuscle

9.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting LDL Across the Whole Spectrum of Chronic Kidney Disease: From Pathophysiology to Novel Treatments.

Current atherosclerosis reports·2026
Same author

How are developments in the treatment armamentarium of hyperphosphatemia addressing the current therapeutic challenges?

Expert opinion on pharmacotherapy·2026
Same author

Missing Opportunity for Nephroprotective Therapy in Patients With Non-Dialysis CKD Under Stable Nephrology Care.

Kidney international reports·2026
Same author

Beyond traditional roles: vitamin D and erythropoietin as immune modulators in kidney diseases.

Clinical kidney journal·2026
Same author

Mineral, Bone, and Cardiovascular Disorders in CKD: The Case for a New Paradigm.

Kidney medicine·2026
Same author

Osteoporosis and CKD-Metabolic Bone Disease Under the Same Umbrella: Insights From a Joint Scientific Symposium.

Kidney international reports·2026

Related Experiment Video

Updated: Apr 19, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.7K

Calcific uremic arteriolopathy: a call for action.

Vincent M Brandenburg1, Mario Cozzolino2, Sandro Mazzaferro3

  • 1Department of Cardiology and Center for Rare Diseases (Zentrum für seltene Erkrankungen Aachen, ZSEA), RWTH University Hospital, Aachen, Germany.

Seminars in Nephrology
|December 16, 2014
PubMed
Summary

Calciphylaxis, a severe skin condition in kidney disease patients, requires urgent research. Understanding its causes and treatments is crucial for improving patient outcomes.

Keywords:
Calciphylaxiscalcific uremic arteriolopathycalcificationchronic kidney diseasevascular disease

More Related Videos

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

4.7K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.7K
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

4.7K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.7K

Area of Science:

  • Nephrology
  • Dermatology
  • Cardiology

Background:

  • Calciphylaxis, or calcific uremic arteriolopathy (CUA), is a serious condition affecting patients with advanced or end-stage renal disease.
  • Diagnosis often occurs in nephrology units, presenting with painful skin lesions that can lead to severe ulcerations and high mortality.
  • Current understanding of CUA development and effective therapeutic strategies remains limited.

Purpose of the Study:

  • To address the stagnancy in CUA research and therapy.
  • To highlight CUA as a critical research target for the CKD-MBD working group.

Main Methods:

  • The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) scientific working group CKD-MBD initiated a call to action.
  • Defining calciphylaxis as a key research priority.

Main Results:

  • Calciphylaxis is recognized as a challenging, multi-disciplinary condition.
  • There is a recognized need for advancements in understanding CUA pathogenesis and treatment.

Conclusions:

  • Calciphylaxis represents a significant unmet need in nephrology, dermatology, and cardiology.
  • Further research into CUA is essential to improve patient morbidity and mortality.