Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

The DNA Helix

The DNA Helix

The DNA Helix

The DNA Helix

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Towards the construction of a virtual yeast.

Nature·2026

Same author

Energy-translation coupling limits anaerobic yeast growth.

Nature communications·2026

Same author

Editorial: Advanced functional materials, structures, and devices for advancing human healthcare applications.

Frontiers in chemistry·2026

Same author

Protein Structuromics Reveals a Loop-Controlled Half-Open Active Pocket Conformation Throughout Fe(II)/α-ketoglutarate-Dependent Dioxygenase Catalytic Cycle.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Leveraging large language models for metabolic engineering design.

Trends in biotechnology·2026

Same author

Nasopharyngeal Bacterial-Fungal Dysbiosis in Respiratory-Diseased Endangered Forest Musk Deer (<i>Moschus berezovskii</i>).

Biology·2026

Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026

Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026

Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026

Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026

Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026

Same journal

Minimal enzyme cascades for the aromatic-to-aromatic upgrading of lignin monomers.

Current opinion in biotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

Recent progress on DNA based walkers.

Jing Pan¹, Feiran Li¹, Tae-Gon Cha¹

¹School of Mechanical Engineering, Purdue University, Mechanical Engineering Building, 585 Purdue Mall, West Lafayette, IN 47907, USA.

Current Opinion in Biotechnology

|December 16, 2014

Summary

This summary is machine-generated.

Synthetic DNA molecular walkers mimic biological motors. Recent advances allow direct observation, enabling analysis of their functions for future applications in nanotechnology.

More Related Videos

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease

Published on: January 18, 2021

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

Related Experiment Videos

Last Updated: Apr 19, 2026

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease

Published on: January 18, 2021

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

Area of Science:

Synthetic biology
Nanotechnology
Molecular machines

Background:

DNA-based synthetic molecular walkers are analogous to biological protein motors.
Their operation relies on fuel strand hybridization, conformational changes, and oligonucleotide chemistry.

Purpose of the Study:

To review recent advancements in DNA walker principles and characterization.
To evaluate the functional aspects of DNA walkers for diverse applications.

Main Methods:

Analysis of recent progress in DNA walker design and synthesis.
Review of experimental techniques for observing individual molecular walkers.
Evaluation of characterization methods for assessing walker performance.

Main Results:

Experimental techniques now allow high-resolution observation of individual DNA walkers.
This enables detailed analysis of their movement and functionality.

Conclusions:

State-of-the-art DNA walker systems show significant potential for various applications.
Further evaluation of their functions is crucial for future development in nanotechnology.