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Effects of graphene oxide on the development of offspring mice in lactation period
Changhui Fu1, Tianlong Liu1, Linlin Li1
1Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Abstract:
The potential toxicity of graphene oxide (GO) has attracted much attention with numerous promising biomedical applications in recent years. However, information about GO on the development of filial animals is rare. In this work, we studied the potential developmental toxicity of GO when they entered the body of maternal mice and their offspring by oral exposure with two doses. The results showed that the increase of body weight, body length and tail length of the filial mice received GO at 0.5 mg mL(-1) (about 0.8 mg each mouse) every day in the lactation period was significantly retarded comparing with the control group. The anatomy and histology results revealed the delayed developments of offspring in high dosage group. We also evaluated the possible toxicological mechanism caused by GO and found that the length of the intestinal villus of the filial mice received high concentration GO were decreased significantly compared with the control group. It can be concluded that GO showed many negative effects on the development of mice in the lactation period. These findings can be significant for the development of graphene materials-based drug delivery system and other biomedical applications in the future.
Insights
Graphene oxide (GO) exposure during lactation retards filial mice development, causing reduced body weight and intestinal villi length. This highlights potential risks for graphene-based biomedical applications.
Area of Science:
- Nanomaterials Science
- Developmental Toxicology
- Biomedical Engineering
Background:
- Graphene oxide (GO) shows promise for biomedical applications.
- Limited data exists on GO's developmental toxicity in offspring.
- Understanding GO's impact on filial development is crucial.
Purpose of the Study:
- To investigate the developmental toxicity of graphene oxide (GO) in maternal mice and their offspring.
- To assess the effects of oral GO exposure on filial growth and development.
- To explore the toxicological mechanisms underlying GO's impact.
Main Methods:
- Oral administration of two doses of GO to maternal mice during lactation.
- Monitoring body weight, body length, and tail length of filial mice.
- Anatomical and histological examination of offspring.
- Evaluation of intestinal villi length as a toxicological indicator.
Main Results:
- Significant retardation in body weight, body length, and tail length in filial mice exposed to GO.
- Delayed development observed in offspring from the high-dose GO group.
- A significant decrease in intestinal villi length in filial mice receiving high-concentration GO.
Conclusions:
- Graphene oxide exhibits significant negative effects on the development of mice during the lactation period.
- GO exposure can lead to developmental delays and reduced intestinal health in offspring.
- Findings are critical for the safe development of graphene-based drug delivery systems and other biomedical uses.
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