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Updated: Apr 19, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and
Joanne J Liu1, Pnina Green2, J John Mann3
1Department of Molecular Imaging & Neuropathology, New York State Psychiatric Institute, New York, NY, USA; New York Medical College, Valhalla, NY, USA.
Abstract:
Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development and function. Abnormalities of PUFA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUFA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUFA utilization, highlighting their relevance to neuropsychiatric disease.
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