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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Updated: Apr 19, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Modern brachytherapy.

J Nicholas Lukens¹, Mauricio Gamez², Kenneth Hu³

¹Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA.

Seminars in Oncology

|December 16, 2014

Summary

This summary is machine-generated.

Recent advancements in imaging and optimization have significantly evolved brachytherapy (radiation therapy). This review highlights trends in high-dose-rate brachytherapy and hypofractionation for common cancers.

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Last Updated: Apr 19, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: June 7, 2015

Area of Science:

Oncology
Radiation Oncology
Medical Physics

Background:

Brachytherapy offers targeted radiation delivery adjacent to or within tumors.
Historically significant, brachytherapy treatment paradigms are rapidly advancing.
Modern brachytherapy leverages imaging for precise applicator placement and volume-based optimization.

Purpose of the Study:

To review recent data and trends in brachytherapy.
To discuss evolving treatment paradigms in common oncologic sites.
To highlight advancements in image-guided brachytherapy and dose fractionation.

Main Methods:

Review of recent scientific literature and clinical data.
Analysis of trends in brachytherapy utilization.
Focus on disease sites commonly treated with brachytherapy.

Main Results:

Significant shift towards high-dose-rate (HDR) brachytherapy.
Increased adoption of hypofractionation (higher doses per fraction) for specific sites.
Improved tumor coverage and normal tissue sparing through image guidance and optimization.

Conclusions:

Brachytherapy continues to evolve with technological advancements.
HDR brachytherapy and hypofractionation are key emerging trends.
These advancements enhance treatment efficacy and patient outcomes across various cancers.